TY - JOUR
T1 - M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis
AU - Zhong, Xingwu
AU - Liu, Hongshan
AU - Pu, Aijun
AU - Xia, Xuefeng
AU - Zhou, Xiaodong
N1 - Funding Information:
Acknowledgment: This work was supported by a grant from NCET (04-0812), the Natural Science Foundation of Guangdong (04105323), Fok Ying Tong Education Foundation, (91043), SRFDP (20050558075), and the National Natural Science Foundation of China (30572007).
PY - 2007/6
Y1 - 2007/6
N2 - Introduction: The objective was to study the pathogenesis of contact lens-associated giant papillary conjunctivitis (CL-GPC). Materials and Methods: Twenty-one biopsies of conjunctival giant papillae were obtained from soft contact lens wearers. The tissues were fixed in 4% paraformaldehyde and embedded in paraffin. Sections of 5 μm thickness were used for studies of histology and immunohistochemistry of pan-B and pan-T cell distributions. Results: Conjunctival epitheliums on the top of conjunctiva-associated lymphoid tissue typically lacked goblet cells. Lymphocytes from underlying lymphoid follicle were pressed into intra-epithelial "pockets" formed through epithelial invagination. Under the follicle-associated epithelium, pan-B cells were mostly gathered in the central folliclar area and intraepithelial pockets, while CD3-positive T cells were predominantly distributed in parafolliclar region, but only a few in the intraepithelial pockets. Conclusions: Membranous epithelial cells (M cells) play a key role in the pathogenesis of CL-GPC for the binding and translocation of antigen and pathogen.
AB - Introduction: The objective was to study the pathogenesis of contact lens-associated giant papillary conjunctivitis (CL-GPC). Materials and Methods: Twenty-one biopsies of conjunctival giant papillae were obtained from soft contact lens wearers. The tissues were fixed in 4% paraformaldehyde and embedded in paraffin. Sections of 5 μm thickness were used for studies of histology and immunohistochemistry of pan-B and pan-T cell distributions. Results: Conjunctival epitheliums on the top of conjunctiva-associated lymphoid tissue typically lacked goblet cells. Lymphocytes from underlying lymphoid follicle were pressed into intra-epithelial "pockets" formed through epithelial invagination. Under the follicle-associated epithelium, pan-B cells were mostly gathered in the central folliclar area and intraepithelial pockets, while CD3-positive T cells were predominantly distributed in parafolliclar region, but only a few in the intraepithelial pockets. Conclusions: Membranous epithelial cells (M cells) play a key role in the pathogenesis of CL-GPC for the binding and translocation of antigen and pathogen.
KW - Contact lens-associated giant papillary conjunctivitis
KW - M cells
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U2 - 10.1007/s00005-007-0022-x
DO - 10.1007/s00005-007-0022-x
M3 - Article
C2 - 17557145
AN - SCOPUS:34250708422
SN - 0004-069X
VL - 55
SP - 173
EP - 177
JO - Archivum Immunologiae et Therapiae Experimentalis
JF - Archivum Immunologiae et Therapiae Experimentalis
IS - 3
ER -