Lysosomal membrane labilization by DDT, DDE and polychlorinated biphenyls (PCB)

A. Rogers, A. Mellors, S. Safe

Research output: Contribution to journalArticle

Abstract

Incubation of the ubiquitous pollutants, polychlorinated biphenyls (PCB), DDT and DDE with rat liver lysosomes shows that these lipophilic substrates are highly active labilizers of lysosomal membranes. The release of acid phosphatase was used as a marker enzyme and at high PCB, DDT and DDE concentrations (2x10-3M) the lytic activity was similar to that of the detergent Triton X 100; at lower concentrations most of the commercial PCB samples, DDT and DDE still retain considerable lytic activity.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume13
Issue number2
StatePublished - 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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