Lymphotactin: A cytokine that represents a new class of chemokine

Gregory S. Kelner, Jacqueline Kennedy, Kevin B. Bacon, Sarah Kleyensteuber, David A. Largaespada, Nancy A. Jenkins, Neal G. Copeland, J. Fernando Bazan, Kevin W. Moore, Thomas J. Schall, Albert Zlotnik

Research output: Contribution to journalArticlepeer-review

613 Scopus citations

Abstract

In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor αβ+ thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.

Original languageEnglish (US)
Pages (from-to)1395-1399
Number of pages5
JournalScience
Volume266
Issue number5189
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • General

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