Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Rie Watanabe-Fukunaga, Camilynn I. Brannan, Neal G. Copeland, Nancy A. Jenkins, Shigekazu Nagata

Research output: Contribution to journalArticle

2643 Scopus citations

Abstract

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoproliferation (lpr) mutation have defects in the Fas antigen gene. The lpr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.

Original languageEnglish (US)
Pages (from-to)314-317
Number of pages4
JournalNature
Volume356
Issue number6367
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • General

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