Abstract
CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5–40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.
Original language | English (US) |
---|---|
Pages (from-to) | 154-163 |
Number of pages | 10 |
Journal | Adipocyte |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 2019 |
Keywords
- Adipose tissue
- CD36
- T cells
- metabolism
- obesity
ASJC Scopus subject areas
- Histology
- Cell Biology