@article{e9c23f3be2e84bbba900ed74300f4d2b,
title = "Lymphocytes upregulate CD36 in adipose tissue and liver",
abstract = "CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5–40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.",
keywords = "Adipose tissue, CD36, T cells, metabolism, obesity",
author = "Jacob Couturier and Nuotio-Antar, {Alli M.} and Neeti Agarwal and Wilkerson, {Gregory K.} and Pradip Saha and Viraj Kulkarni and Lakhashe, {Samir K.} and Juan Esquivel and Nehete, {Pramod N.} and Ruprecht, {Ruth M.} and Sastry, {K. Jagannadha} and Meyer, {Jennifer M.} and Hill, {Lori R.} and Lake, {Jordan E.} and Ashok Balasubramanyam and Lewis, {Dorothy E.}",
note = "Funding Information: This work was supported by NIH/NIAID grants R21 AI116208 (DEL and AB) and R33 AI116208 (DEL and AB). This investigation used resources that were supported by the Southwest National Primate Research Center grant P51 OD011133 from the Office of Research Infrastructure Programs, National Institutes of Health. RMR acknowledges NIH/NIDCR grant R01 DE023049. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2019",
month = jan,
day = "2",
doi = "10.1080/21623945.2019.1609202",
language = "English (US)",
volume = "8",
pages = "154--163",
journal = "Adipocyte",
issn = "2162-3945",
publisher = "Taylor and Francis Ltd.",
number = "1",
}