Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation

Venessa A. Holland, Philip T. Cagle, Nancy T. Windsor, George P. Noon, S. Donald Greenberg, E. Clinton Lawrence

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolitis obliterans following heart-lung transplantation.

Original languageEnglish (US)
Pages (from-to)955-959
Number of pages5
JournalTransplantation
Volume50
Issue number6
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Transplantation

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