Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation

Venessa A. Holland; Philip T. Cagle; Nancy T. Windsor; George P. Noon; S. Donald Greenberg; E. Clinton Lawrence

doi:10.1097/00007890-199012000-00011

Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation

Venessa A. Holland, Philip T. Cagle, Nancy T. Windsor, George P. Noon, S. Donald Greenberg, E. Clinton Lawrence

Academic Institute

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolitis obliterans following heart-lung transplantation.

Original language	English (US)
Pages (from-to)	955-959
Number of pages	5
Journal	Transplantation
Volume	50
Issue number	6
DOIs	https://doi.org/10.1097/00007890-199012000-00011
State	Published - Jan 1 1990

ASJC Scopus subject areas

Transplantation

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title = "Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation",

abstract = "The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolitis obliterans following heart-lung transplantation.",

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AU - Holland, Venessa A.

AU - Cagle, Philip T.

AU - Windsor, Nancy T.

AU - Noon, George P.

AU - Greenberg, S. Donald

AU - Lawrence, E. Clinton

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolitis obliterans following heart-lung transplantation.

AB - The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolitis obliterans following heart-lung transplantation.

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Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation

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