Abstract
The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolitis obliterans following heart-lung transplantation.
Original language | English (US) |
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Pages (from-to) | 955-959 |
Number of pages | 5 |
Journal | Transplantation |
Volume | 50 |
Issue number | 6 |
DOIs | |
State | Published - Jan 1 1990 |
ASJC Scopus subject areas
- Transplantation