LXR is crucial in lipid metabolism

Stine Marie Ulven, Knut Tomas Dalen, Jan Åke Gustafsson, Hilde Irene Nebb

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily and are activated by oxysterols and intermediates in the cholesterol synthetic pathway. The pivotal role of LXRs in the metabolic conversion of cholesterol to bile acids is well established. Analysis of gene expression in LXRα and LXRβ deficient mice have confirmed that LXR regulates a number of target genes involved in both cholesterol and fatty acid metabolism in liver, macrophages and intestine. The observation that LXRα is responsive to fatty acids and is expressed in metabolic tissues suggests that it also plays a general role in lipid metabolism. Adipose tissue is the main storage site for fat in the body and plays a crucial role in overall lipid handling. Both LXRα and LXRβ are expressed and activated by endogenous and synthetic ligands, which lead to lipid accumulation into adipocytes. This indicates an important regulatory role of LXR in several metabolic signaling pathways in the adipose tissue, such as glucose uptake and de novo fatty acid synthesis. Here, we review recent studies that provide new insights into the mechanisms by which LXRs act to influence fatty acid synthesis in liver and adipose tissue.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume73
Issue number1 SPEC. ISS.
DOIs
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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