Abstract
The present study addresses the insulin sensitivity in mice deficient in LXRβ (LXRβ-/-) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRβ-/- mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRβ-/- mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRβ-/- mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRβ-/- mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks.
Original language | English (US) |
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Pages (from-to) | 436-441 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 392 |
Issue number | 3 |
DOIs | |
State | Published - Feb 12 2010 |
Keywords
- Glucose
- Hepatic steatosis
- Insulin
- Insulin clearance
- LXR
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Molecular Biology