LXRβ deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp

Sverre Holm, Peter J. Voshol, Jan Åke Gustafsson, Hilde I. Nebb

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    The present study addresses the insulin sensitivity in mice deficient in LXRβ (LXRβ-/-) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRβ-/- mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRβ-/- mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRβ-/- mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRβ-/- mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks.

    Original languageEnglish (US)
    Pages (from-to)436-441
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume392
    Issue number3
    DOIs
    StatePublished - Feb 12 2010

    Keywords

    • Glucose
    • Hepatic steatosis
    • Insulin
    • Insulin clearance
    • LXR

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Cell Biology
    • Molecular Biology

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