LXRβ deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp

Sverre Holm, Peter J. Voshol, Jan Åke Gustafsson, Hilde I. Nebb

Research output: Contribution to journalArticle

Abstract

The present study addresses the insulin sensitivity in mice deficient in LXRβ (LXRβ-/-) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRβ-/- mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRβ-/- mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRβ-/- mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRβ-/- mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks.

Original languageEnglish (US)
Pages (from-to)436-441
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume392
Issue number3
DOIs
StatePublished - Feb 12 2010

Keywords

  • Glucose
  • Hepatic steatosis
  • Insulin
  • Insulin clearance
  • LXR

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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