Lung tumor induction in strain A mice with benzotrichloride

Gary D. Stoner, Ming You, Mary A. Morgan, Melody J. Superczynski

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Benzotrichloride (BTC) is used in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. In the present study, BTC was evaluated for its ability to induce lung adenomas in strain A J mice. Four groups of 15 male and 15 female A J mice were injected i.p. with either tricaprylin or BTC in tricaprylin three times a week for 8 weeks. BTC groups received doses totaling 1440 mg/kg, 719 mg/kg or 287 mg/kg. The mean number of lung tumors per mouse was 127 87 ± 5.81, 43 ± 2.44, and 17.73 ± 1.09 in the groups treated with either 1440 mg/kg, 719 mg/kg, or 287 mg/kg, respectively. Tricaprylin-vehicle controls had a mean number of 0.46 ± 0.15 lung tumors per mouse. Therefore, BTC produced a significant (P < 0.001) and dose-related increase in the lung tumor response when compared to tricaprylin controls and is a potent carcinogen in the strain A mouse lung tumor bioassay.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalCancer Letters
Volume33
Issue number2
DOIs
StatePublished - Nov 1986

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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