TY - JOUR
T1 - Lung Cancer Presenting as Skin Metastasis of the Back and Hand
T2 - A Case Series and Literature Review
AU - Khaja, Misbahuddin
AU - Mundt, Daniel
AU - Dudekula, Rizwan Ahmed
AU - Ashraf, Umair
AU - Mehershahi, Shehriyar
AU - Niazi, Masooma
AU - Lvovsky, Dimitry
AU - Malik, Sandeep
AU - Diaz-Fuentes, Gilda
N1 - Funding Information:
No financial support was used for this case report.
Publisher Copyright:
© 2019 The Author(s) Published by S. Karger AG, Basel.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Lung cancer has the highest mortality of all cancers in the United States. The incidence of lung cancer with metastases to the skin varies between 1-12%, with the highest incidence seen in men. Here, we present two cases of lung cancer presenting as skin metastasis. The first patient was an 80-year-old African American male who presented to the hospital for evaluation of a right upper back mass. A few months prior to admission, he was found to have a left lung mass on CT scan of the chest, he underwent biopsy which showed poorly differentiated SCC of the lung. He also had a skin biopsy which showed poorly differentiated carcinoma in the dermis consistent with metastatic SCC. He was started on chemotherapy, but could not tolerate it. He was accepted to hospice. The second patient was a 78-year-old Hispanic female who presented to the hospital with dyspnea, and a dry cough. Upon physical examination, a 2 × 2 cm ulcerated, wart-like nodule on the right palm was noted. Subsequent CT scan of the chest showed a partial collapse of the right middle lobe. A biopsy of the hand mass revealed well-to-moderately differentiated metastatic SCC favoring lung origin. A bronchoscopy biopsy showed invasive SCC. Subsequently her condition worsened and she passed away. Metastasis to the skin is an unusual presenting symptom of lung cancer. It is therefore essential to consider metastasis as a diagnosis in a patient with both a skin lesion and a smoking history.
AB - Lung cancer has the highest mortality of all cancers in the United States. The incidence of lung cancer with metastases to the skin varies between 1-12%, with the highest incidence seen in men. Here, we present two cases of lung cancer presenting as skin metastasis. The first patient was an 80-year-old African American male who presented to the hospital for evaluation of a right upper back mass. A few months prior to admission, he was found to have a left lung mass on CT scan of the chest, he underwent biopsy which showed poorly differentiated SCC of the lung. He also had a skin biopsy which showed poorly differentiated carcinoma in the dermis consistent with metastatic SCC. He was started on chemotherapy, but could not tolerate it. He was accepted to hospice. The second patient was a 78-year-old Hispanic female who presented to the hospital with dyspnea, and a dry cough. Upon physical examination, a 2 × 2 cm ulcerated, wart-like nodule on the right palm was noted. Subsequent CT scan of the chest showed a partial collapse of the right middle lobe. A biopsy of the hand mass revealed well-to-moderately differentiated metastatic SCC favoring lung origin. A bronchoscopy biopsy showed invasive SCC. Subsequently her condition worsened and she passed away. Metastasis to the skin is an unusual presenting symptom of lung cancer. It is therefore essential to consider metastasis as a diagnosis in a patient with both a skin lesion and a smoking history.
KW - Metastatic skin lesion
KW - Non small cell lung cancer
KW - Squamous cell lung cancer
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U2 - 10.1159/000501363
DO - 10.1159/000501363
M3 - Article
AN - SCOPUS:85068603610
SN - 1662-6575
VL - 12
SP - 480
EP - 487
JO - Case Reports in Oncology
JF - Case Reports in Oncology
IS - 2
ER -