Luminal gastric somatostatin-like immunoreactivity in response to various stimuli in man

Halil Degertekin, Atilla Ertan, Kemal Akdamar, Kate Groot, Tejas Godiwala, Frances J. Mather, Akira Arimura

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

This study investigates release of somatostatin-like immunoreactivity (SLI) into the gastric lumen of five healthy human subjects in response to pharmacological stimuli (pentagastrin and secretin) and physiological stimuli (sham feeding and intrajejunal perfusion of elemental diet). Basal and poststimulation gastric juice aspirates were collected at 15-min intervals, extracted with acetone, and SLI determined by radioimmunoassay, with these results: (1) A considerable amount of SLI was secreted during the basal period. (2) Pentagastrin stimulated SLI release quickly and was associated with increased acid secretion. (3) Both secretin and sham feeding increased SLI only slightly. (4) During intrajejunal perfusion of the elemental diet, SLI increased significantly, was associated with decreased acid secretion, and rapidly returned to basal level when elemental diet was replaced by saline. Basal levels of gastric luminal SLI thus showed distinct changes in response to each stimulus. Although the physiological action of luminal SLI remains to be studied, its levels may reflect gastric D-cell activities.

Original languageEnglish (US)
Pages (from-to)833-839
Number of pages7
JournalDigestive Diseases and Sciences
Volume31
Issue number8
DOIs
StatePublished - Aug 1986
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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