Luminal conversion and immunoregulation by probiotics

Bhanu Priya Ganesh, James Versalovic

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Beneficial microbes are responsible for the synthesis of nutrients and metabolites that are likely important for the maintenance of mammalian health. Many nutrients and metabolites derived from the gut microbiota by luminal conversion have been implicated in the development, homeostasis and function of innate and adaptive immunity. These factors clearly suggest that intestinal microbiota may influence host immunity via microbial metabolite-dependent mechanisms. We describe how intestinal microbes including probiotics generate microbial metabolites that modulate mucosal and systemic immunity.

Original languageEnglish (US)
Article number277
JournalFrontiers in Pharmacology
Issue numberNOV
StatePublished - 2015


  • Commensal bacteria
  • Diet
  • Dietary compounds
  • Immunomodulation
  • Metabolites
  • Microbiome
  • Probiotics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


Dive into the research topics of 'Luminal conversion and immunoregulation by probiotics'. Together they form a unique fingerprint.

Cite this