Luminal conversion and immunoregulation by probiotics

Bhanu Priya Ganesh, James Versalovic

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Beneficial microbes are responsible for the synthesis of nutrients and metabolites that are likely important for the maintenance of mammalian health. Many nutrients and metabolites derived from the gut microbiota by luminal conversion have been implicated in the development, homeostasis and function of innate and adaptive immunity. These factors clearly suggest that intestinal microbiota may influence host immunity via microbial metabolite-dependent mechanisms. We describe how intestinal microbes including probiotics generate microbial metabolites that modulate mucosal and systemic immunity.

Original languageEnglish (US)
Article number277
JournalFrontiers in Pharmacology
Volume6
Issue numberNOV
DOIs
StatePublished - 2015

Keywords

  • Commensal bacteria
  • Diet
  • Dietary compounds
  • Immunomodulation
  • Metabolites
  • Microbiome
  • Probiotics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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