TY - JOUR
T1 - Low lifetime recreational activity is a risk factor for peripheral arterial disease
AU - Wilson, Andrew M.
AU - Sadrzadeh-Rafie, Amir H.
AU - Myers, Jonathan
AU - Assimes, Themistocles
AU - Nead, Kevin T.
AU - Higgins, Mamie
AU - Gabriel, Andre
AU - Olin, Jeffrey
AU - Cooke, John P.
N1 - Funding Information:
This study was supported in part by grants from the National Heart, Lung and Blood Institute ( RO 1 HL-075774 and K12 HL087746 ; JPC), and NIH grant M01 RR 00070 (General Clinical Research Center, Stanford University School of Medicine).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Background: The relationship between lifetime physical activity and the risk of developing peripheral arterial disease (PAD) is not known. Methods: We studied 1381 patients referred for elective coronary angiography in a point prevalence analysis. PAD was defined as ankle-brachial index (ABI) <0.9 at the time or a history of revascularization of the lower extremities regardless of ABI measure. We used a validated physical activity questionnaire to retrospectively measure each patient's lifetime recreational activity (LRA). Multivariate and logistic regression analyses were used to assess the independent association of LRA to ABI and the presence of PAD. Results: PAD was present in 19% (n = 258) of all subjects. Subjects reporting no regular LRA had greater diastolic blood pressure and were more likely to be female. They had lower average ABI, and a higher proportion had PAD (25.6%). In a regression model, including traditional risk factors and LRA, multivariate analysis showed that age (P <.001), female gender (P <.001), systolic blood pressure (P =.014), fasting glucose (P <.001), serum triglycerides (P =.02), and cumulative pack years (P <.001) were independent negative predictors of ABI, and LRA was a positive predictor of ABI (P <.001). History of sedentary lifestyle independently increased the odds ratio for PAD (odds ratio, 0.46; 95% confidence interval, 1.01-2.10) when assessed by logistic regression. Intriguingly, there is a correlation between physical activity and gender, such that women with low LRA are at greatest risk. Conclusion: Recalled LRA is positively correlated to ABI and associated with PAD. Whereas the mechanism for this effect is not clear, LRA may be a useful clinical screening tool for PAD risk, and strategies to increase adult recreational activity may reduce the burden of PAD later in life.
AB - Background: The relationship between lifetime physical activity and the risk of developing peripheral arterial disease (PAD) is not known. Methods: We studied 1381 patients referred for elective coronary angiography in a point prevalence analysis. PAD was defined as ankle-brachial index (ABI) <0.9 at the time or a history of revascularization of the lower extremities regardless of ABI measure. We used a validated physical activity questionnaire to retrospectively measure each patient's lifetime recreational activity (LRA). Multivariate and logistic regression analyses were used to assess the independent association of LRA to ABI and the presence of PAD. Results: PAD was present in 19% (n = 258) of all subjects. Subjects reporting no regular LRA had greater diastolic blood pressure and were more likely to be female. They had lower average ABI, and a higher proportion had PAD (25.6%). In a regression model, including traditional risk factors and LRA, multivariate analysis showed that age (P <.001), female gender (P <.001), systolic blood pressure (P =.014), fasting glucose (P <.001), serum triglycerides (P =.02), and cumulative pack years (P <.001) were independent negative predictors of ABI, and LRA was a positive predictor of ABI (P <.001). History of sedentary lifestyle independently increased the odds ratio for PAD (odds ratio, 0.46; 95% confidence interval, 1.01-2.10) when assessed by logistic regression. Intriguingly, there is a correlation between physical activity and gender, such that women with low LRA are at greatest risk. Conclusion: Recalled LRA is positively correlated to ABI and associated with PAD. Whereas the mechanism for this effect is not clear, LRA may be a useful clinical screening tool for PAD risk, and strategies to increase adult recreational activity may reduce the burden of PAD later in life.
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U2 - 10.1016/j.jvs.2011.02.052
DO - 10.1016/j.jvs.2011.02.052
M3 - Article
C2 - 21664093
AN - SCOPUS:79961169198
SN - 0741-5214
VL - 54
SP - 427-432.e4
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 2
ER -