@inproceedings{987a201860104a4494a6c51844d15784,
title = "Low Intensity Repetitive Transcranial Magnetic Stimulation Modulates Spontaneous Spiking Activities in Rat Cortex",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique for neuromodulation. Even at low intensities, rTMS can alter the structure and function of neural circuits; yet the underlying mechanism remains unclear. Here we report a new experimental paradigm for studying the effect of low intensity rTMS (LI-rTMS) on single neuron spiking activities in the sensorimotor cortex of anesthetized rats. We designed, built, and tested a miniaturized TMS coil for use on small animals such as rats. The induced electric field in different 3D locations was measured along different directions using a dipole probe. A maximum electric field strength of 2.3 V/m was achieved. LI-rTMS (10 Hz, 3 min) was delivered to the rat primary motor and somatosensory cortices. Single-unit activities were recorded before and after LI-rTMS. Results showed that LI-rTMS increased the spontaneous firing rates of primary motor and somatosensory cortical neurons. Diverse modulatory patterns were observed in different neurons. These results indicated the feasibility of using miniaturized coil in rodents as an experimental platform for evaluating the effect of LI-rTMS on the brain and developing therapeutic strategies for treating neurological disorders.",
author = "Wenxuan Jiang and Robert Isenhart and Natalie Kistler and Zhouxiao Lu and Huijing Xu and Lee, {Darrin J.} and Liu, {Charles Y.} and Dong Song",
note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 ; Conference date: 01-11-2021 Through 05-11-2021",
year = "2021",
doi = "10.1109/EMBC46164.2021.9630986",
language = "English (US)",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "6318--6321",
booktitle = "43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021",
address = "United States",
}