Low-grade serous primary peritoneal carcinoma

Kathleen M. Schmeler, Charlotte C. Sun, Anais Malpica, Michael T. Deavers, Diane C. Bodurka, David M. Gershenson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objective: 10% of women with serous ovarian cancer have low-grade carcinomas. These patients are diagnosed at a younger age, have a longer overall survival and a lower response rate to platinum-based chemotherapy compared to women with high-grade serous ovarian carcinoma. It remains unclear if these features are similar in women with low-grade primary peritoneal cancer (PPC). To further explore this issue, a retrospective analysis of the clinical and pathologic characteristics of women with low-grade serous PPC was performed. Methods: A retrospective study of 53 patients with low-grade serous PPC evaluated at a single institution from 1986 to 2009 was performed. All cases were reviewed by a gynecologic pathologist to confirm low-grade serous PPC. Results: Median age at diagnosis was 51.7 years (range 27.1-82.4). 46 patients (86.8%) underwent primary surgery, with optimal tumor reduction achieved in 30 patients (65.2%). 48 patients (90.6%) received chemotherapy as part of their initial treatment. At the completion of primary treatment, 66.7% of patients were noted to have persistent or progressive disease. With a median follow-up of 66.1 months, the 5-year PFS was 16%, yet the 5-year OS was 69%. Conclusion: To our knowledge, this is the first report of women with low-grade serous PPC. Similar to low-grade serous ovarian carcinoma, patients with low-grade serous PPC have high rates of persistent disease at the completion of primary treatment yet a long overall survival. Further study focusing specifically on low-grade serous ovarian and primary peritoneal carcinomas is needed to determine the optimal treatment of these diseases.

Original languageEnglish (US)
Pages (from-to)482-486
Number of pages5
JournalGynecologic oncology
Issue number3
StatePublished - Jun 1 2011


  • Low-grade serous carcinoma
  • Ovarian cancer
  • Primary peritoneal cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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