Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China

J. Zhao; Y. Wang; Haiyingo Wang; C. Jiang; Z. Liu; X. Meng; G. Song; N. Cheng; E. A. Graviss; X. Ma

Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China

J. Zhao, Y. Wang, Haiyingo Wang, C. Jiang, Z. Liu, X. Meng, G. Song, N. Cheng, E. A. Graviss, X. Ma

Research output: Contribution to journal › Article › peer-review

Abstract

T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4-15.9) and 24.9% (95%CI 21.5-28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6-75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7-24.2) and 23.7% (95%CI 17.3-31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4-79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.

Original language	English (US)
Pages (from-to)	134-136
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	15
Issue number	1
State	Published - Jan 2011

Keywords

IFN-γ
Latent tuberculosis infection
T-SPOT®.TB
Tuberculin skin test

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

Cite this

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title = "Low agreement between the T-SPOT{\textregistered}.TB assay and the tuberculin skin test among college students in China",

abstract = "T-SPOT{\textregistered}.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT{\textregistered}.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4-15.9) and 24.9% (95%CI 21.5-28.6) among students with a bacille Calmette-Gu{\'e}rin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6-75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7-24.2) and 23.7% (95%CI 17.3-31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4-79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.",

keywords = "IFN-γ, Latent tuberculosis infection, T-SPOT{\textregistered}.TB, Tuberculin skin test",

author = "J. Zhao and Y. Wang and Haiyingo Wang and C. Jiang and Z. Liu and X. Meng and G. Song and N. Cheng and Graviss, {E. A.} and X. Ma",

year = "2011",

month = jan,

language = "English (US)",

volume = "15",

pages = "134--136",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union against Tubercul. and Lung Dis.",

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T1 - Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China

AU - Zhao, J.

AU - Wang, Y.

AU - Wang, Haiyingo

AU - Jiang, C.

AU - Liu, Z.

AU - Meng, X.

AU - Song, G.

AU - Cheng, N.

AU - Graviss, E. A.

AU - Ma, X.

PY - 2011/1

Y1 - 2011/1

N2 - T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4-15.9) and 24.9% (95%CI 21.5-28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6-75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7-24.2) and 23.7% (95%CI 17.3-31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4-79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.

AB - T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4-15.9) and 24.9% (95%CI 21.5-28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6-75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7-24.2) and 23.7% (95%CI 17.3-31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4-79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.

KW - IFN-γ

KW - Latent tuberculosis infection

KW - T-SPOT®.TB

KW - Tuberculin skin test

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Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China

Abstract

Keywords

ASJC Scopus subject areas

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