Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China

J. Zhao, Y. Wang, Haiyingo Wang, C. Jiang, Z. Liu, X. Meng, G. Song, N. Cheng, E. A. Graviss, X. Ma

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4-15.9) and 24.9% (95%CI 21.5-28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6-75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7-24.2) and 23.7% (95%CI 17.3-31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4-79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.

Original languageEnglish (US)
Pages (from-to)134-136
Number of pages3
JournalInternational Journal of Tuberculosis and Lung Disease
Volume15
Issue number1
StatePublished - Jan 2011

Keywords

  • IFN-γ
  • Latent tuberculosis infection
  • T-SPOT®.TB
  • Tuberculin skin test

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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