Low admission triglyceride and mortality in acute coronary syndrome patients

Owais A. Khawaja, Hazem Hatahet, Joao Cavalcante, Sanjaya Khanal, Mouaz Al-Mallah

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: The relationship between admission triglyceride (TG) levels and long-term outcomes has not been established in patients with acute coronary syndrome. We tested the hypothesis that patients who develop non-ST segment elevation myocardial infarction (NSTEMI) despite low TG have a worse cardiovascular outcome in the long term. Methods: Patients admitted with NSTEMI between 1 January 1997 and 31 December 2000 and with fasting lipid profiles measured within 24 hours of admission were included for analysis. Baseline characteristics and three-year all-cause mortality were compared between the patients with TG above and below the median. Multivariate analysis was used to determine the predictors of all-cause mortality and adjusted survival was analyzed using the Cox proportional hazard model. Results: Of 517 patients, 395 had TG ≤ 200 mg/dL and 124 had TG > 200 mg/dL. Patients with low TG were more often Caucasian, with no significant differences in gender or severity of coronary artery disease between the two groups. There was a trend for increased all-cause mortality at six months (9% vs 3%, p = 0.045) and three years (13.4% vs 5.6%, p = 0.016) in patients with low TG. In multivariate analysis, low TG level at admission was an independent predictor of increased mortality at three years (adjusted OR 2.5, 95% CI = 1.04-5.9, p = 0.04). Conclusions: In our cohort, lower TG at admission is associated with increased three-year mortality in patients with NSTEMI. Whether this is a result of current therapy, or a marker for worse baseline characteristics, needs to be studied further.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalCardiology Journal
Volume18
Issue number3
StatePublished - Jun 23 2011

Keywords

  • Mortality
  • Non-sT segment elevation myocardial infarction
  • Triglyceride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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