Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

Alex Koufos; Marc F. Hansen; Neal G. Copeland; Nancy A. Jenkins; Beatrice C. Lampkin; Webster K. Cavenee

doi:10.1038/316330a0

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

Alex Koufos, Marc F. Hansen, Neal G. Copeland, Nancy A. Jenkins, Beatrice C. Lampkin, Webster K. Cavenee

Research output: Contribution to journal › Article › peer-review

442 Scopus citations

Abstract

Children with the Beckwith-Wiedeman syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanisms that entails the somatic development of homozygosity for a mutant allele at a locus on human chromosome 11.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Nature
Volume	316
Issue number	6026
DOIs	https://doi.org/10.1038/316330a0
State	Published - Dec 1 1985

ASJC Scopus subject areas

General

Access to Document

10.1038/316330a0

Cite this

@article{401c46998ffe4d95bf8881001b34d2b9,

title = "Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism",

abstract = "Children with the Beckwith-Wiedeman syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanisms that entails the somatic development of homozygosity for a mutant allele at a locus on human chromosome 11.",

author = "Alex Koufos and Hansen, {Marc F.} and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Lampkin, {Beatrice C.} and Cavenee, {Webster K.}",

year = "1985",

month = dec,

day = "1",

doi = "10.1038/316330a0",

language = "English (US)",

volume = "316",

pages = "330--334",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6026",

}

TY - JOUR

T1 - Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

AU - Koufos, Alex

AU - Hansen, Marc F.

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Lampkin, Beatrice C.

AU - Cavenee, Webster K.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - Children with the Beckwith-Wiedeman syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanisms that entails the somatic development of homozygosity for a mutant allele at a locus on human chromosome 11.

AB - Children with the Beckwith-Wiedeman syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanisms that entails the somatic development of homozygosity for a mutant allele at a locus on human chromosome 11.

UR - http://www.scopus.com/inward/record.url?scp=0021932813&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021932813&partnerID=8YFLogxK

U2 - 10.1038/316330a0

DO - 10.1038/316330a0

M3 - Article

C2 - 2991766

AN - SCOPUS:0021932813

SN - 0028-0836

VL - 316

SP - 330

EP - 334

JO - Nature

JF - Nature

IS - 6026

ER -

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this