Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice

Keyphrases

• Inflammation 100%
• Receptor Signaling 100%
• Tumorigenesis 100%
• Histamine 100%
• 2 Receptor 100%
• Neutrophil Homeostasis 100%
• Neutrophils 45%
• Receptor Activation 36%
• RNA Sequencing (RNA-seq) 27%
• Intestinal Epithelial Cells 18%
• Colitis 18%
• High Density 18%
• Low-density Neutrophils 18%
• Gene-deficient Mice 9%
• Mouse Model 9%
• Reduced Expression 9%
• Toll-like 9%
• Quantitative PCR 9%
• T Cell Proliferation 9%
• Mitogen-activated Protein Kinase 9%
• Infiltration 9%
• Inflammatory Response 9%
• Nuclear factor-B 9%
• Innate Immune Cells 9%
• Peritoneum 9%
• Immune Cells 9%
• Relative Abundance 9%
• Low Density 9%
• Centrifugation 9%
• Method Analysis 9%
• Downstream Effects 9%
• Colonic Tumor 9%
• Colon Tumor 9%
• Murine Neutrophils 9%
• Dextran Sulfate Sodium 9%
• Maturation Markers 9%
• Histamine Receptors 9%
• Pathway Signaling 9%
• Neutrophil Differentiation 9%
• Online Database 9%
• MYC Pathway 9%
• Single-cell RNA Sequencing (scRNA-seq) 9%
• Neutrophil Maturation 9%

Biochemistry, Genetics and Molecular Biology

• Homeostasis 100%
• Carcinogenesis 100%
• Histamine 100%
• RNA Sequence 36%
• Maturation 18%
• Wild Type 18%
• Immunocompetent Cell 18%
• Cell Proliferation 9%
• extracellular signal regulated kinase 9%
• Quantitative Reverse Transcription Polymerase Chain Reaction 9%
• Mouse Model 9%
• T Cell 9%
• Complement Factor B 9%
• Colon 9%
• Centrifugation 9%
• Sulfate 9%
• Dextran 9%
• TLR4 9%
• Histamine H4 Receptor 9%

Immunology and Microbiology

• Homeostasis 100%
• Neutrophil 100%
• Histamine 100%
• RNA Sequence 33%
• Wild Type 16%
• Maturation 16%
• Colitis 16%
• Mouse Model 8%
• Mitogen 8%
• T Cell Proliferation 8%
• Quantitative Reverse Transcription Polymerase Chain Reaction 8%
• Colon 8%
• Complement Factor B 8%
• Immunocompetent Cell 8%
• TLR4 8%
• Centrifugation 8%
• Innate Immune Cell 8%