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Lorentz force megahertz optical coherence elastography

Chen Wu, Manmohan Singh, Zhaolong Han, Raksha Raghunathan, Chih Hao Liu, Jiasong Li, Alexander Schill, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical Coherence Elastography (OCE) is a rapidly developing technique for assessing tissue biomechanical properties. This study demonstrates the first use of the Lorentz force to induce elastic waves within tissue to quantify the elasticity of tissue in combination with a phase-sensitive OCE system at ∼1.5 million A-scans per second. The feasibility of this technique was tested on tissue-mimicking agar phantoms of various concentrations. The results as assessed by OCE were in good agreement with standard mechanical testing of the samples. After the preliminary experiments, the stiffness of porcine liver was examined. The results demonstrate that Lorentz force MHz OCE can be applied to study the elasticity of biological tissue effectively and has the potential for clinical applications due to rapid excitation and imaging.

Original languageEnglish (US)
Title of host publicationOptical Elastography and Tissue Biomechanics III
EditorsDavid D. Sampson, Kirill V. Larin
PublisherSPIE
ISBN (Electronic)9781628419443
DOIs
StatePublished - 2016
EventOptical Elastography and Tissue Biomechanics III - San Francisco, United States
Duration: Feb 13 2016Feb 15 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9710
ISSN (Print)1605-7422

Conference

ConferenceOptical Elastography and Tissue Biomechanics III
Country/TerritoryUnited States
CitySan Francisco
Period2/13/162/15/16

Keywords

  • biomechanical property
  • Lorentz force
  • Optical Coherence Elastography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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