Abstract
INTRODUCTION:Bile duct involvement is a key finding of primary biliary cholangitis (PBC). The aim of this study was to evaluate baseline ductopenia and disease progression.METHODS:Retrospective longitudinal histological follow-up of treatment-naive patients with PBC.RESULTS:Eighty-three patients were included, with ductopenia correlated to fibrosis stage at baseline. The cumulative incidence of severe ductopenia remained stable after 5 years, whereas fibrosis continually increased over time. Baseline AST-to-Platelet Ratio Index and elevated alkaline phosphatase >2 times the normal with abnormal bilirubin were associated with ductopenia progression.DISCUSSION:Bile duct injury does not seem to follow the same course as fibrosis in PBC.
Original language | English (US) |
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Pages (from-to) | 2075-2078 |
Number of pages | 4 |
Journal | American Journal of Gastroenterology |
Volume | 117 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2022 |
ASJC Scopus subject areas
- Hepatology
- Gastroenterology