Longitudinal Assessment of Bile Duct Loss in Primary Biliary Cholangitis

Julian Hercun, Mazen Noureddin, Nabil Noureddin, Jason Eccleston, Daniel Woolridge, T. Jake Liang, Michele Tana, David E. Kleiner, Gracia Viana Rodriguez, Christopher Koh, Jay H. Hoofnagle, Theo Heller

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


INTRODUCTION:Bile duct involvement is a key finding of primary biliary cholangitis (PBC). The aim of this study was to evaluate baseline ductopenia and disease progression.METHODS:Retrospective longitudinal histological follow-up of treatment-naive patients with PBC.RESULTS:Eighty-three patients were included, with ductopenia correlated to fibrosis stage at baseline. The cumulative incidence of severe ductopenia remained stable after 5 years, whereas fibrosis continually increased over time. Baseline AST-to-Platelet Ratio Index and elevated alkaline phosphatase >2 times the normal with abnormal bilirubin were associated with ductopenia progression.DISCUSSION:Bile duct injury does not seem to follow the same course as fibrosis in PBC.

Original languageEnglish (US)
Pages (from-to)2075-2078
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number12
StatePublished - Dec 1 2022

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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