Long-term stability of a patient-convenient 1 mg/ml suspension of tacrolimus for accurate maintenance of stable therapeutic levels

A Elefante, J Muindi, K West, L Dunford, S Abel, P Paplham, K Brown, T Hahn, S Padmanabhan, M Battiwalla, P L McCarthy

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Tacrolimus (Prograf, FK506, Fujisawa Healthcare) is a widely used immunosuppressive agent that is used both for the prevention and treatment of solid organ transplant rejection as well as for the prevention and treatment of graft-versus-host disease after allogeneic blood and marrow transplant. Oral preparations of tacrolimus are commercially available in 0.5, 1 and 5 mg gelatin capsules. Previously, only a 0.5 mg/ml oral suspension has been demonstrated to be stable for use in pediatric patients. On our bone marrow transplant service, we found that using this concentration of tacrolimus led to confusion, with patients and their caregivers confusing milligrams and milliliters, thus increasing errors with this formulation. We postulated that a 1 mg/ml oral formulation of tacrolimus would decrease the potential for medication errors. Our findings support new stability information of approximately 4 months for an extemporaneous oral suspension of tacrolimus at a concentration of 1 mg/ml.

Original languageEnglish (US)
Pages (from-to)781-4
Number of pages4
JournalBone Marrow Transplantation
Volume37
Issue number8
DOIs
StatePublished - Apr 2006

Keywords

  • Administration, Oral
  • Bone Marrow Transplantation
  • Chromatography, High Pressure Liquid
  • Dose-Response Relationship, Drug
  • Graft vs Host Disease
  • Humans
  • Immunosuppressive Agents
  • Models, Statistical
  • Specimen Handling
  • Tacrolimus
  • Time Factors
  • Transplantation, Homologous
  • Journal Article

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