Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes

Helen E. Heslop; Catherine Y.C. Ng; Congfen Li; Colton A. Smith; Susan K. Loftin; Roberta Krance; Malcolm K. Brenner; Cliona M. Rooney

doi:10.1038/nm0596-551

Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes

Helen E. Heslop, Catherine Y.C. Ng, Congfen Li, Colton A. Smith, Susan K. Loftin, Roberta Krance, Malcolm K. Brenner, Cliona M. Rooney

Research output: Contribution to journal › Article › peer-review

724 Scopus citations

Abstract

Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) offers safe and effective therapy for certain viral infections and could prove useful in the eradication of tumor cells. Whether or not the infused T cells persist for extended periods, retaining their ability to expand in response to antigenic stimulation, is not known. We now report long-term detection of gene-marked Epstein-Barr virus (EBV)-specific CTLs in immunocompromised patients at risk for the development of EBV lymphoproliferative disease. Infusions of CTLs not only restored cellular immune responses against EBV, but also established populations of CTL precursors that could respond to in vivo or ex vivo challenge with the virus for as long as 18 months. Our findings support wider use of antigen-specific CTLs in adoptive immunotherapy.

Original language	English (US)
Pages (from-to)	551-555
Number of pages	5
Journal	Nature Medicine
Volume	2
Issue number	5
DOIs	https://doi.org/10.1038/nm0596-551
State	Published - 1996

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes",

abstract = "Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) offers safe and effective therapy for certain viral infections and could prove useful in the eradication of tumor cells. Whether or not the infused T cells persist for extended periods, retaining their ability to expand in response to antigenic stimulation, is not known. We now report long-term detection of gene-marked Epstein-Barr virus (EBV)-specific CTLs in immunocompromised patients at risk for the development of EBV lymphoproliferative disease. Infusions of CTLs not only restored cellular immune responses against EBV, but also established populations of CTL precursors that could respond to in vivo or ex vivo challenge with the virus for as long as 18 months. Our findings support wider use of antigen-specific CTLs in adoptive immunotherapy.",

author = "Heslop, {Helen E.} and Ng, {Catherine Y.C.} and Congfen Li and Smith, {Colton A.} and Loftin, {Susan K.} and Roberta Krance and Brenner, {Malcolm K.} and Rooney, {Cliona M.}",

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AU - Heslop, Helen E.

AU - Ng, Catherine Y.C.

AU - Li, Congfen

AU - Smith, Colton A.

AU - Loftin, Susan K.

AU - Krance, Roberta

AU - Brenner, Malcolm K.

AU - Rooney, Cliona M.

PY - 1996

Y1 - 1996

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AB - Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) offers safe and effective therapy for certain viral infections and could prove useful in the eradication of tumor cells. Whether or not the infused T cells persist for extended periods, retaining their ability to expand in response to antigenic stimulation, is not known. We now report long-term detection of gene-marked Epstein-Barr virus (EBV)-specific CTLs in immunocompromised patients at risk for the development of EBV lymphoproliferative disease. Infusions of CTLs not only restored cellular immune responses against EBV, but also established populations of CTL precursors that could respond to in vivo or ex vivo challenge with the virus for as long as 18 months. Our findings support wider use of antigen-specific CTLs in adoptive immunotherapy.

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Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes

Abstract

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