Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy

Thao Vo, Yan Xing, Funda Meric-Bernstam, Nadeem Mirza, Georges Vlastos, W. Fraser Symmans, George H. Perkins, Thomas A. Buchholz, Gildy V. Babiera, Henry M. Kuerer, Isabelle Bedrosian, Jeri S. Akins, Kelly K. Hunt

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Background: Mucinous, medullary, and tubular carcinomas are uncommon types of breast cancer whose rarity does not permit large single-institution studies or randomized trials to define optimal treatments. In this study, we evaluated the long-term outcomes of breast-conserving therapy (BCT) for these subtypes of breast cancer and compared them with those for invasive ductal carcinoma. Methods: In our institutional database of patients who received BCT from 1965 to 1999, 1,643 patients with stage I to II mucinous (61), medullary (37), tubular (60), and invasive ductal (1,485) histologies were identified. The clinical and pathologic features of the 4 groups were evaluated and compared with respect to local-regional recurrence rates, disease-free survival, and overall survival (OS). Results: No statistically significant differences were found in the local-regional failure rate among the 4 groups (10.6-year median follow-up). Only patients with tubular carcinoma had better 5- and 10-year OS rates (P = .013). In multivariable analysis, factors associated with improved OS included age at or below 50 years, negative nodal status, use of chemotherapy or hormonal therapy, and tubular histology. Conclusions: BCT for mucinous, medullary, or tubular carcinoma resulted in similar local-regional failure rates to that for invasive ductal carcinoma. Tubular carcinoma patients had the most favorable OS. BCT is an appropriate treatment strategy for early-stage mucinous, medullary, and tubular carcinomas.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalAmerican Journal of Surgery
Issue number4
StatePublished - Oct 2007


  • Breast cancer
  • Breast-conservation therapy
  • Invasive ductal carcinoma
  • Lumpectomy
  • Medullary carcinoma
  • Mucinous carcinoma
  • Tubular carcinoma

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy'. Together they form a unique fingerprint.

Cite this