Dolgoročni učinki presaditve matičnih celic pri bolnikih s srčnim popuščanjem

Translated title of the contribution: Long-term effects of stem cell transplantation in heart failure

Bojan Vrtovec, Matjaz Sever, Dragoslav Domanovic, Luka Lezaic, Gregor Poglajen, Peter Cernelc, François Haddad, Guillermo Torre-Amione

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: We investigated long-term effects of intracoronary transplantation of CD34+ cells in patients with dilated cardiomyopathy (DCM). Methods: Of 110 DCM patients, 55 were randomized to CD34+ cell transplantation (SC) group, and 55 patients received no cell therapy (controls). In the SC group, peripheral CD34+cells were mobilized by G-CSF and collected via apheresis. Patients underwent myocardial scintigraphy and CD34+ cells were injected in the artery supplying the segments with reduced viability. Patients were followed for 5 years. Results: At baseline, the 2 groups did not differ in age, gender, left ventricular ejection fraction (LVEF), or NT-proBNP levels. At 5 years, stem cell therapy was associated with an increase in LVEF (from 24.3 ± 6.5 % to 30.0 ± 5.1 %; P = 0.02), an increase in 6-minute walk distance (from 344 ± 90 m to 477 ± 130 m; P < 0.001), and a decrease in NT-proBNP (from 2322 ± 1234 pg/mL to 1011 ± 893 pg/mL; P < 0.01). During followup, 27 (25 %) patients died and 9 (8 %) underwent heart transplantation. Of the 27 deaths, 13 were attributed to pump failure, and 14 to sudden cardiac death. Total mortality was lower in SC group (8/55 [14 %]) than in controls (19/55 [35 %]) (P = 0.01). The same was true of pump failure (3/55 [5 %] vs. 10/55 [18 %], P = 0.03), but not of sudden cardiac death (5/55 [9 %] vs. 9/55 [16 %], P = 0.39). SC therapy was an independent predictor of outcome on multivariable analysis (P = 0.04). Conclusions: Intracoronary stem cell transplantation may be associated with improved ventricular remodeling, exercise tolerance, and longterm survival in patients with DCM.

Translated title of the contributionLong-term effects of stem cell transplantation in heart failure
Original languageSlovenian
Pages (from-to)373-383
Number of pages11
JournalZdravniski Vestnik
Volume81
Issue numberSUPPL.2
StatePublished - 2012

Keywords

  • Dilated cardiomyopathy
  • Heart failure
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Long-term effects of stem cell transplantation in heart failure'. Together they form a unique fingerprint.

Cite this