Long-term effects of lanthanum intake on the neurobehavioral development of the rat

Liuxing Feng, Haiqing Xiao, Xiao He, Zijie Li, Fuliang Li, Nianqing Liu, Zhifang Chai, Yuliang Zhao, Zhiyong Zhang

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameters and neurobehaviors were assessed, including body weight gain, pinna detachment, eye opening, surface righting reflex and swimming endurance. At 30 days of age, DNA concentration and protein / DNA ratio of the whole brain were determined. At 150 days of age, the Morris water maze test was carried out to study the memory and learning abilities of the rats. Differences were found in the body weight gain, surface righting reflex and swimming endurance. Moreover, lanthanum exposure significantly altered the DNA concentration and Protein/DNA in brain. The Morris water maze test showed that lanthanum exposure at 40 mg/kg significantly impaired memory and learning abilities. These findings indicate that lanthanum is a potential behavior teratogen. The information provided by this work should be considered in future applications of lanthanides.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalNeurotoxicology and Teratology
Volume28
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Central nervous system
  • Lanthanum
  • Neurobehavioral development

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

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