Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice

Longshan Liu, Changxi Wang, Xiaoshun He, Wenjun Shang, Ying Bi, Dong Wang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

This study was performed to observe the long-term effect of FTY720 on lymphocyte count change and islet allograft survival. Diabetic C57BL/6 mice were given FTY720 (group 1, 0.5 mg/kg/day; group 2, 1.0 mg/kg/day) or its vehicle (group 3, controls) after transplantation. Median graft survival time was prolonged in a dose-dependent manner (group 1, 84.5 days; group 2, >100 days, and group 3, 10 days, P < 0.01). Peripheral blood lymphocytes in groups 1 and 2 decreased to 23.81% and 12.59% compared with control group after FTY720 treatment. Lymphocytes from mesenteric lymph nodes and axillary nodes in groups 1 and 2 significantly increased on day 5, but decreased on day 14. Lymphocyte infiltration to the graft site was attenuated in groups 1 and 2. In conclusion, continuous FTY720 administration can induce and maintain lymphopenia, and inhibit lymphocytes from infiltrating the graft site so as to prolong islet allograft survival in mice.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalMicrosurgery
Volume27
Issue number4
DOIs
StatePublished - Jun 15 2007

ASJC Scopus subject areas

  • Surgery

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