@article{6eecf192c564409ab17f55c65fdaf69c,
title = "Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient",
abstract = "We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying blaNDM-1 and an extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.",
keywords = "Cefiderocol, Chronic osteomyelitis, ESBL-producing klebsiella pneumoniae, Pediatric, XDR pseudomonas aeruginosa",
author = "Alamarat, {Zain I.} and Jessica Babic and Tran, {Truc T.} and Wootton, {Susan H.} and Dinh, {An Q.} and Miller, {William R.} and Blake Hanson and Audrey Wanger and Gary, {Joshua L.} and Arias, {Cesar A.} and Norma P{\'e}rez",
note = "Funding Information: C.A.A. is supported by NIH/NIAID grants R01 AI134637, R21 AI143229, and K24 AI121296, a UTHealth Presidential Award, a University of Texas System STARS Award, and the Texas Medical Center Health Policy Institute Funding Program. W.R.M. is supported by NIH/NIAID grant K08 AI135093. C.A.A. has received grant support from Merck, Inc., Entasis Therapeutics pharmaceuticals, and MeMed Diagnostics. W.R.M. has received grant support from Merck and Entasis Therapeutics and honoraria from Achaogen and Shionogi. Publisher Copyright: Copyright {\textcopyright} 2020 American Society for Microbiology. All Rights Reserved.",
year = "2020",
doi = "10.1128/AAC.01872-19",
language = "English (US)",
volume = "64",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "4",
}