Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient

Zain I. Alamarat; Jessica Babic; Truc T. Tran; Susan H. Wootton; An Q. Dinh; William R. Miller; Blake Hanson; Audrey Wanger; Joshua L. Gary; Cesar A. Arias; Norma Pérez

doi:10.1128/AAC.01872-19

Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient

Zain I. Alamarat, Jessica Babic, Truc T. Tran, Susan H. Wootton, An Q. Dinh, William R. Miller, Blake Hanson, Audrey Wanger, Joshua L. Gary, Cesar A. Arias, Norma Pérez

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying bla_NDM-1 and an extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.

Original language	English (US)
Article number	e01872-19
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	4
DOIs	https://doi.org/10.1128/AAC.01872-19
State	Published - 2020

Keywords

Cefiderocol
Chronic osteomyelitis
ESBL-producing klebsiella pneumoniae
Pediatric
XDR pseudomonas aeruginosa

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Alamarat, Z. I., Babic, J., Tran, T. T., Wootton, S. H., Dinh, A. Q., Miller, W. R., Hanson, B., Wanger, A., Gary, J. L., Arias, C. A., & Pérez, N. (2020). Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient. Antimicrobial Agents and Chemotherapy, 64(4), Article e01872-19. https://doi.org/10.1128/AAC.01872-19

Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient. / Alamarat, Zain I.; Babic, Jessica; Tran, Truc T. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 64, No. 4, e01872-19, 2020.

Research output: Contribution to journal › Article › peer-review

Alamarat, ZI, Babic, J, Tran, TT, Wootton, SH, Dinh, AQ, Miller, WR , Hanson, B, Wanger, A, Gary, JL, Arias, CA & Pérez, N 2020, 'Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient', Antimicrobial Agents and Chemotherapy, vol. 64, no. 4, e01872-19. https://doi.org/10.1128/AAC.01872-19

Alamarat ZI, Babic J, Tran TT, Wootton SH, Dinh AQ, Miller WR et al. Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient. Antimicrobial Agents and Chemotherapy. 2020;64(4):e01872-19. doi: 10.1128/AAC.01872-19

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abstract = "We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying blaNDM-1 and an extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.",

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AU - Wootton, Susan H.

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AU - Arias, Cesar A.

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AB - We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying blaNDM-1 and an extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.

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Long-term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient

Abstract

Keywords

ASJC Scopus subject areas

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