Long non-coding RNAs in recurrent ovarian cancer: Theranostic perspectives

Vipul Bhardwaj; Yan Qin Tan; Ming Ming Wu; Lan Ma; Tao Zhu; Peter E. Lobie; Vijay Pandey

doi:10.1016/j.canlet.2020.12.042

Long non-coding RNAs in recurrent ovarian cancer: Theranostic perspectives

Vipul Bhardwaj, Yan Qin Tan, Ming Ming Wu, Lan Ma, Tao Zhu, Peter E. Lobie, Vijay Pandey

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Nearly 70% of ovarian cancer (OC) patients experience recurrence within the first 2 years after initial treatment. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a pivotal role in the pathogenesis of OC progression, resistance to therapy and recurrent OC (ROC). Transcriptome profiling studies have reported differential expression patterns of lncRNAs in OC which are related to increased cell invasion, metastasis and drug resistance. In this review, we highlighted the roles of lncRNAs in OC progression and outlined the potential molecular mechanisms by which lncRNAs impact on ROC. Recent advances using lncRNAs as potential biomarkers for screening, detection, prediction, response to therapy and as therapeutic targets are discussed.

Original language	English (US)
Pages (from-to)	97-107
Number of pages	11
Journal	Cancer Letters
Volume	502
DOIs	https://doi.org/10.1016/j.canlet.2020.12.042
State	Published - Apr 1 2021

Keywords

Cancer biomarker
Drug resistance
LncRNA
Metastasis
ROC
Recurrence

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2020.12.042

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title = "Long non-coding RNAs in recurrent ovarian cancer: Theranostic perspectives",

abstract = "Nearly 70% of ovarian cancer (OC) patients experience recurrence within the first 2 years after initial treatment. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a pivotal role in the pathogenesis of OC progression, resistance to therapy and recurrent OC (ROC). Transcriptome profiling studies have reported differential expression patterns of lncRNAs in OC which are related to increased cell invasion, metastasis and drug resistance. In this review, we highlighted the roles of lncRNAs in OC progression and outlined the potential molecular mechanisms by which lncRNAs impact on ROC. Recent advances using lncRNAs as potential biomarkers for screening, detection, prediction, response to therapy and as therapeutic targets are discussed.",

keywords = "Cancer biomarker, Drug resistance, LncRNA, Metastasis, ROC, Recurrence",

author = "Vipul Bhardwaj and Tan, {Yan Qin} and Wu, {Ming Ming} and Lan Ma and Tao Zhu and Lobie, {Peter E.} and Vijay Pandey",

note = "Funding Information: This work was supported by the Overseas Research Cooperation Project ( HW2020008 ) (Tsinghua Shenzhen International Graduate School), China ; the Shenzhen Development and Reform Commission Subject Construction Project ( [2017]1434 ), China; TBSI Faculty Start-up Funds, China and The Shenzhen Bay Laboratory, China . Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = apr,

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doi = "10.1016/j.canlet.2020.12.042",

language = "English (US)",

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T2 - Theranostic perspectives

AU - Bhardwaj, Vipul

AU - Tan, Yan Qin

AU - Wu, Ming Ming

AU - Ma, Lan

AU - Zhu, Tao

AU - Lobie, Peter E.

AU - Pandey, Vijay

N1 - Funding Information: This work was supported by the Overseas Research Cooperation Project ( HW2020008 ) (Tsinghua Shenzhen International Graduate School), China ; the Shenzhen Development and Reform Commission Subject Construction Project ( [2017]1434 ), China; TBSI Faculty Start-up Funds, China and The Shenzhen Bay Laboratory, China . Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Nearly 70% of ovarian cancer (OC) patients experience recurrence within the first 2 years after initial treatment. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a pivotal role in the pathogenesis of OC progression, resistance to therapy and recurrent OC (ROC). Transcriptome profiling studies have reported differential expression patterns of lncRNAs in OC which are related to increased cell invasion, metastasis and drug resistance. In this review, we highlighted the roles of lncRNAs in OC progression and outlined the potential molecular mechanisms by which lncRNAs impact on ROC. Recent advances using lncRNAs as potential biomarkers for screening, detection, prediction, response to therapy and as therapeutic targets are discussed.

AB - Nearly 70% of ovarian cancer (OC) patients experience recurrence within the first 2 years after initial treatment. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a pivotal role in the pathogenesis of OC progression, resistance to therapy and recurrent OC (ROC). Transcriptome profiling studies have reported differential expression patterns of lncRNAs in OC which are related to increased cell invasion, metastasis and drug resistance. In this review, we highlighted the roles of lncRNAs in OC progression and outlined the potential molecular mechanisms by which lncRNAs impact on ROC. Recent advances using lncRNAs as potential biomarkers for screening, detection, prediction, response to therapy and as therapeutic targets are discussed.

KW - Cancer biomarker

KW - Drug resistance

KW - LncRNA

KW - Metastasis

KW - ROC

KW - Recurrence

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JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

ER -

Long non-coding RNAs in recurrent ovarian cancer: Theranostic perspectives

Abstract

Keywords

ASJC Scopus subject areas

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