Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells

Carmen Lanzillotti, Monica De Mattei, Chiara Mazziotta, Francesca Taraballi, John Charles Rotondo, Mauro Tognon, Fernanda Martini

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with microRNAs (miRNAs), play a pivotal role in osteogenesis. While miRNA action mechanism relies mainly on miRNA-mRNA interaction, resulting in suppressed expression, lncRNAs affect mRNA functionality through different activities, including interaction with miRNAs. Recent advances in RNA sequencing technology have improved knowledge into the molecular pathways regulated by the interaction of lncRNAs and miRNAs. This review reports on the recent knowledge of lncRNAs and miRNAs roles as key regulators of osteogenic differentiation. Specifically, we described herein the recent discoveries on lncRNA-miRNA crosstalk during the osteogenic differentiation of mesenchymal stem cells (MSCs) derived from bone marrow (BM), as well as from different other anatomical regions. The deep understanding of the connection between miRNAs and lncRNAs during the osteogenic differentiation will strongly improve knowledge into the molecular mechanisms of bone growth and development, ultimately leading to discover innovative diagnostic and therapeutic tools for osteogenic disorders and bone diseases.

Original languageEnglish (US)
Article number646032
Pages (from-to)646032
JournalFrontiers in Cell and Developmental Biology
StatePublished - Apr 9 2021


  • crosstalk
  • interplay
  • lncRNA
  • long non-coding RNA
  • mesenchymal stem cell
  • miRNA
  • microRNA
  • osteogenic differentiation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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