Long Interspersed Nuclear Element (LINE-1/L1)

K. S. Ramos, P. Bojang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Long Interspersed Nuclear Element-1 (Line-1/L1) is the only active autonomous mobile element in the human genome. When activated and mobilized in cis or trans, L1 can induce DNA recombination and breaks, regulate gene structure and function, and influence chromosome organization. These activities have been associated with human disease, genetic variation, genome evolution, and somatic mosaicism, depending on cellular context. Organisms have thus evolved multiple defense mechanisms to restrict L1 expression and retrotransposition, such as transcriptional epigenetic silencing, L1 mRNA deamination and degradation, cytoplasmic sequestration and degradation of L1 mRNAs and proteins, inhibition of target prime insertion, cryptic polyadenation, and non-processive reverse transcription. Consequently, L1 expression is undetectable in most somatic tissues, except for brain and testes. However, reactivation of L1 has been detected in various disease states and upon exposure to various forms of cellular and tissue injury.

Original languageEnglish (US)
Title of host publicationComprehensive Toxicology, Third Edition
Subtitle of host publicationVolume 1-15
PublisherElsevier
PagesV8-626-V8-643
Volume8
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - Jan 1 2018

Keywords

  • Aryl hydrocarbon receptor
  • DNA damage
  • Endonuclease
  • Environmental carcinogens
  • Epigenetic modifications
  • LINE-1 mobilization
  • LINE-1 reactivation
  • LINE-1 retrotransposition
  • Reverse transcriptase

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)

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