LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer

Jie Li, Zhongqiu Zhang, Zunyan Dai, Christoph Plass, Carl Morrison, Yian Wang, Jonathan S. Wiest, Marshall W. Anderson, Ming You

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Previous observation has shown that the wild-type Kras2 allele is a suppressor of lung cancer in mice. Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in ∼50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in ∼40% of adenocarcinomas and large cell carcinomas. Interestingly, all of the lung adenocarcinomas and large cell carcinomas containing a Kras2 mutation exhibited allelic loss of the wild-type Kras2 allele when a correlation between LOH of the region on chromosome 12p and Kras2 mutation was made. These results from human lung cancer tissues provide a strong evidence in support of our previous observation in mouse models that the wild-type Kras2 is a tumor suppressor of lung cancer.

Original languageEnglish (US)
Pages (from-to)1243-1246
Number of pages4
JournalOncogene
Volume22
Issue number8
DOIs
StatePublished - Feb 27 2003

Keywords

  • Loss of heterozygosity
  • Lung cancer
  • Mutations
  • Tumor suppressor
  • Wild-type Kras2

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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