TY - JOUR
T1 - Locomotor step training with body weight support improves respiratory motor function in individuals with chronic spinal cord injury
AU - Terson de Paleville, Daniela
AU - McKay, William
AU - Aslan, Sevda
AU - Folz, Rodney
AU - Sayenko, Dimitry
AU - Ovechkin, Alexander
N1 - Funding Information:
This work was supported by grants from University of Louisville ( UofL/IRI 50814 ); Paralyzed Veterans of America Research Foundation ( PVA RFG 2613 ); Christopher and Dana Reeves Foundation ( CDRF OA2-0802-2 ); and National Institutes of Health ( R01NS049209 , P01NS16333 , and 1R01HL103750 ).
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - This prospective case-controlled clinical study was undertaken to investigate to what extent the manually assisted treadmill stepping locomotor training with body weight support (LT) can change respiratory function in individuals with chronic spinal cord injury (SCI). Pulmonary function outcomes (forced vital capacity /FVC/, forced expiratory volume one second /FEV1/, maximum inspiratory pressure /PImax/, maximum expiratory pressure /PEmax/) and surface electromyographic (sEMG) measures of respiratory muscles activity during respiratory tasks were obtained from eight individuals with chronic C3-T12 SCI before and after 62±10 (mean±SD) sessions of the LT. FVC, FEV1, PImax, PEmax, amount of overall sEMG activity and rate of motor unit recruitment were significantly increased after LT (p<0.05). These results suggest that these improvements induced by the LT are likely the result of neuroplastic changes in spinal neural circuitry responsible for the activation of respiratory muscles preserved after injury.
AB - This prospective case-controlled clinical study was undertaken to investigate to what extent the manually assisted treadmill stepping locomotor training with body weight support (LT) can change respiratory function in individuals with chronic spinal cord injury (SCI). Pulmonary function outcomes (forced vital capacity /FVC/, forced expiratory volume one second /FEV1/, maximum inspiratory pressure /PImax/, maximum expiratory pressure /PEmax/) and surface electromyographic (sEMG) measures of respiratory muscles activity during respiratory tasks were obtained from eight individuals with chronic C3-T12 SCI before and after 62±10 (mean±SD) sessions of the LT. FVC, FEV1, PImax, PEmax, amount of overall sEMG activity and rate of motor unit recruitment were significantly increased after LT (p<0.05). These results suggest that these improvements induced by the LT are likely the result of neuroplastic changes in spinal neural circuitry responsible for the activation of respiratory muscles preserved after injury.
KW - Locomotor training
KW - Motor control
KW - Respiratory function
KW - Spinal cord injury
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U2 - 10.1016/j.resp.2013.08.018
DO - 10.1016/j.resp.2013.08.018
M3 - Article
C2 - 23999001
AN - SCOPUS:84888009340
VL - 189
SP - 491
EP - 497
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 3
ER -