Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy

Yiye Li, Tao Wen, Ruifang Zhao, Xixi Liu, Tianjiao Ji, Hai Wang, Xiaowei Shi, Jian Shi, Jingyan Wei, Yuliang Zhao, Xiaochun Wu, Guangjun Nie

Research output: Contribution to journalArticlepeer-review

214 Scopus citations


Near-infrared plasmonic nanoparticles demonstrate great potential in disease theranostic applications. Herein a nanoplatform, composed of mesoporous silica-coated gold nanorods (AuNRs), is tailor-designed to optimize the photodynamic therapy (PDT) for tumor based on the plasmonic effect. The surface plasmon resonance of AuNRs was fine-tuned to overlap with the exciton absorption of indocyanine green (ICG), a near-infrared photodynamic dye with poor photostability and low quantum yield. Such overlap greatly increases the singlet oxygen yield of incorporated ICG by maximizing the local field enhancement, and protecting the ICG molecules against photodegradation by virtue of the high absorption cross section of the AuNRs. The silica shell strongly increased ICG payload with the additional benefit of enhancing ICG photostability by facilitating the formation of ICG aggregates. As-fabricated AuNR@SiO2 - ICG nanoplatform enables trimodal imaging, near-infrared fluorescence from ICG, and two-photon luminescence/photoacoustic tomography from the AuNRs. The integrated strategy significantly improved photodynamic destruction of breast tumor cells and inhibited the growth of orthotopic breast tumors in mice, with mild laser irradiation, through a synergistic effect of PDT and photothermal therapy. Our study highlights the effect of local field enhancement in PDT and demonstrates the importance of systematic design of nanoplatform to greatly enhancing the antitumor efficacy.

Original languageEnglish (US)
Pages (from-to)11529-11542
Number of pages14
JournalACS Nano
Issue number11
StatePublished - Nov 25 2014


  • Gold nanorod
  • Local field enhancement
  • Photodynamic therapy
  • Photosensitizer
  • Photothermal therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy'. Together they form a unique fingerprint.

Cite this