Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis

Arthur M. Buchberg; Nancy A. Jenkins; Neal G. Copeland

doi:10.1016/0888-7543(89)90071-2

Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis

Arthur M. Buchberg, Nancy A. Jenkins, Neal G. Copeland

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Abstract

The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease.

Original language	English (US)
Pages (from-to)	363-367
Number of pages	5
Journal	Genomics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(89)90071-2
State	Published - Aug 1989

ASJC Scopus subject areas

Genetics

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@article{91d42ec921bd4a07a8869cf804dbaa20,

title = "Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis",

abstract = "The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease.",

author = "Buchberg, \{Arthur M.\} and Jenkins, \{Nancy A.\} and Copeland, \{Neal G.\}",

note = "Funding Information: ,Joanne Diets, Bryn Eagleson, and Mary Dickinson for excellent technical assistance. We thank Linda D. Siracusa for critically reviewing the manuscript. The research was supported by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with Bio-netirs Research. Inc. The NCI-Frederick Cancer Research Facility is fully accredited by the American Association for Accreditation of Laboratory Animal Care. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1989",

month = aug,

doi = "10.1016/0888-7543(89)90071-2",

language = "English (US)",

volume = "5",

pages = "363--367",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "2",

}

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T1 - Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis

AU - Buchberg, Arthur M.

AU - Jenkins, Nancy A.

AU - Copeland, Neal G.

N1 - Funding Information: ,Joanne Diets, Bryn Eagleson, and Mary Dickinson for excellent technical assistance. We thank Linda D. Siracusa for critically reviewing the manuscript. The research was supported by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with Bio-netirs Research. Inc. The NCI-Frederick Cancer Research Facility is fully accredited by the American Association for Accreditation of Laboratory Animal Care. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1989/8

Y1 - 1989/8

N2 - The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease.

AB - The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease.

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U2 - 10.1016/0888-7543(89)90071-2

DO - 10.1016/0888-7543(89)90071-2

M3 - Article

C2 - 2676841

AN - SCOPUS:0024708163

SN - 0888-7543

VL - 5

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EP - 367

JO - Genomics

JF - Genomics

IS - 2

ER -

Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis

Abstract

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