Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis

Arthur M. Buchberg, Nancy A. Jenkins, Neal G. Copeland

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalGenomics
Volume5
Issue number2
DOIs
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Genetics

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