Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression

Roman A. Sukhovershin; Naama E. Toledano Furman; Ennio Tasciotti; Barry H. Trachtenberg

doi:10.14797/mdcj-12-3-141

Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression

Roman A. Sukhovershin, Naama E. Toledano Furman, Ennio Tasciotti, Barry H. Trachtenberg

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.

Original language	English (US)
Pages (from-to)	141-145
Number of pages	5
Journal	Methodist DeBakey cardiovascular journal
Volume	12
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-12-3-141
State	Published - Sep 2016

Keywords

atherosclerosis
macrophage
nanoparticle
nanotechnology
plaque
smooth muscle cell

ASJC Scopus subject areas

General Medicine

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10.14797/mdcj-12-3-141

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abstract = "Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.",

keywords = "atherosclerosis, macrophage, nanoparticle, nanotechnology, plaque, smooth muscle cell",

author = "Sukhovershin, {Roman A.} and {Toledano Furman}, {Naama E.} and Ennio Tasciotti and Trachtenberg, {Barry H.}",

year = "2016",

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AU - Sukhovershin, Roman A.

AU - Toledano Furman, Naama E.

AU - Tasciotti, Ennio

AU - Trachtenberg, Barry H.

PY - 2016/9

Y1 - 2016/9

N2 - Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.

AB - Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.

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KW - macrophage

KW - nanoparticle

KW - nanotechnology

KW - plaque

KW - smooth muscle cell

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Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression

Abstract

Keywords

ASJC Scopus subject areas

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