Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression

Roman A. Sukhovershin, Naama E. Toledano Furman, Ennio Tasciotti, Barry H. Trachtenberg

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Volume12
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • atherosclerosis
  • macrophage
  • nanoparticle
  • nanotechnology
  • plaque
  • smooth muscle cell

ASJC Scopus subject areas

  • General Medicine

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