Local cryoglobulin deposition in primary central nervous system lymphoma

Paisit Paueksakon, Mark Shaya, Richard Harper, John Hicks, Luan Truong, J. Clay Goodman, Suzanne Zein-Eldin Powell

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin's B-cell lymphomas confined to the central nervous system. Recent years have brought a dramatic increase in the frequency of PCNSL in the immunocompromised and immunocompetent populations. Cryoglobulins are cold-precipitable immunoglobulins associated with a number of infectious, autoimmune, and neoplastic disorders. Although it is known that patients with hematologic malignancies (eg, B-cell lymphomas, chronic lymphocytic leukemia, plasma cell dyscrasias) may have cryoglobulinemias and cryoglobulin deposition in several organs (eg, kidney, liver skin, blood vessels, peripheral nervous system), PCNSL associated with cryoglobulin deposition has not been previously described. This report demonstrates localized cryoglobulin deposition within the tumor bed in an immunocompetent patient with PCNSL.

Original languageEnglish (US)
Pages (from-to)720-724
Number of pages5
JournalHuman Pathology
Volume34
Issue number7
DOIs
StatePublished - Jul 1 2003

Keywords

  • Cryoglobulinemia
  • Dysproteinemia
  • Electron microscopy
  • Primary central nervous system lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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