Living donor vs. deceased donor liver transplantation for patients with hepatitis C virus-related diseases

Anbin Hu, Wenhua Liang, Zheng Zheng, Zhiyong Guo, Xiaoshun He

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background & Aims: Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LDLT remain controversial. Here we sought to compare the post-transplant outcomes after LDLT and DDLT. Methods: A systematic review and meta-analysis were performed. PubMed/MEDLINE, EMBASE, and the Cochrane database were searched for eligible literatures. The major end points were patient survival, graft survival, recurrence rate, and acute rejection. The pooled odds ratio (OR) was calculated using random-effects model to synthesize the results. Heterogeneity and publication bias were quantitatively evaluated. Results: Fourteen studies with a total of 2024 participants were included in this analysis. We found comparable patient survival between groups (1-year: OR, 0.78, 95% CI, 0.48-1.26, p = 0.31; 2-year: OR, 0.71, 95% CI, 0.41-1.23, p = 0.23; 3-year: OR, 0.79, 95% CI, 0.5-1.12, p = 0.18; 4-year: OR, 0.92, 95% CI, 0.43-1.95, p = 0.83; 5-year: OR, 1.06, 95% CI, 0.53-2.14, p = 0.86, respectively). Although 1- and 3-year graft survivals were inferior in LDLT, 2-, 4- and 5-year graft survivals were similar. HCV recurrence rates and acute rejection rates were equivalent. Conclusions: LDLT was equivalent to DDLT in terms of patient survival, long-term graft survival, HCV recurrence, and acute rejection rates, with potentially lower short-term patient and graft survival.

Original languageEnglish (US)
Pages (from-to)1228-1243
Number of pages16
JournalJournal of Hepatology
Volume57
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • Deceased donor liver transplantation
  • Hepatitis C
  • Living donor liver transplantation
  • Meta-analysis

ASJC Scopus subject areas

  • Hepatology

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