Liver X receptors as regulators of metabolism

Marion Korach-André, Jan Åke Gustafsson

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways. Modulation of LXR and their downstream targets has appeared to be a promising treatment for metabolic diseases especially atherosclerosis and cholesterol metabolism. However, the complexity of LXR action in various metabolic tissues and the liver side effect of LXR activation have slowed down the interest for LXR drugs. In this review, we summarized the role of LXR in the main metabolically active tissues with a special focus on obesity and associated diseases in mammals. We will also discuss the dual interplay between the two LXR isoforms suggesting that they may collaborate to establish a fine and efficient system for the maintenance of metabolism homeostasis.

Original languageEnglish (US)
Pages (from-to)177-190
Number of pages14
JournalBiomolecular Concepts
Volume6
Issue number3
DOIs
StatePublished - Jun 1 2015

Keywords

  • cholesterol
  • nuclear receptor
  • oxysterol
  • transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Liver X receptors as regulators of metabolism'. Together they form a unique fingerprint.

Cite this