Liver X receptors as regulators of metabolism

Marion Korach-André, Jan Åke Gustafsson

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways. Modulation of LXR and their downstream targets has appeared to be a promising treatment for metabolic diseases especially atherosclerosis and cholesterol metabolism. However, the complexity of LXR action in various metabolic tissues and the liver side effect of LXR activation have slowed down the interest for LXR drugs. In this review, we summarized the role of LXR in the main metabolically active tissues with a special focus on obesity and associated diseases in mammals. We will also discuss the dual interplay between the two LXR isoforms suggesting that they may collaborate to establish a fine and efficient system for the maintenance of metabolism homeostasis.

Original languageEnglish (US)
Pages (from-to)177-190
Number of pages14
JournalBiomolecular Concepts
Issue number3
StatePublished - Jun 1 2015


  • cholesterol
  • nuclear receptor
  • oxysterol
  • transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience


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