TY - JOUR
T1 - Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity
AU - Dahlman, Ingrid
AU - Nilsson, Maria
AU - Jiao, Hong
AU - Hoffstedt, Johan
AU - Lindgren, Cecilia M.
AU - Humphreys, Keith
AU - Kere, Juha
AU - Gustafsson, Jan Åke
AU - Arner, Peter
AU - Dahlman-Wright, Karin
PY - 2006/12
Y1 - 2006/12
N2 - OBJECTIVE: LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity. METHODS: LXRA and LXRB mRNAs were quantified in abdominal subcutaneous adipose tissue of obese and nonobese women. The LXRA and LXRB genes were screened for polymorphisms and common single nucleotide polymorphisms genotyped in obese and nonobese women. RESULTS: Relative LXRA mRNA expression levels were higher in obese women (P=0.03). One LXRA single nucleotide polymorphism, rs2279238, and one common haplotype, CAAGCC, as well as two LXRB single nucleotide polymorphisms, LB44732G>A and rs2695121, were associated with obesity phenotypes (nominal P values of 0.0075, 0.0014, 0.008 and 0.02, respectively). Furthermore, there was evidence of interaction between LXRA and LXRB alleles in determining body mass index. CONCLUSION: Our results support a role for LXRA in human adipose tissue. The nominal associations of LXRA and LXRB alleles with obesity are interesting and should be further investigated in independent data sets.
AB - OBJECTIVE: LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity. METHODS: LXRA and LXRB mRNAs were quantified in abdominal subcutaneous adipose tissue of obese and nonobese women. The LXRA and LXRB genes were screened for polymorphisms and common single nucleotide polymorphisms genotyped in obese and nonobese women. RESULTS: Relative LXRA mRNA expression levels were higher in obese women (P=0.03). One LXRA single nucleotide polymorphism, rs2279238, and one common haplotype, CAAGCC, as well as two LXRB single nucleotide polymorphisms, LB44732G>A and rs2695121, were associated with obesity phenotypes (nominal P values of 0.0075, 0.0014, 0.008 and 0.02, respectively). Furthermore, there was evidence of interaction between LXRA and LXRB alleles in determining body mass index. CONCLUSION: Our results support a role for LXRA in human adipose tissue. The nominal associations of LXRA and LXRB alleles with obesity are interesting and should be further investigated in independent data sets.
KW - Adipose tissue
KW - Gene
KW - Insulin sensitivity
KW - LXR
KW - Nuclear receptor
KW - Transcription factor
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U2 - 10.1097/01.fpc.0000236334.49422.48
DO - 10.1097/01.fpc.0000236334.49422.48
M3 - Article
C2 - 17108812
AN - SCOPUS:33751095644
SN - 1744-6872
VL - 16
SP - 881
EP - 889
JO - Pharmacogenetics and Genomics
JF - Pharmacogenetics and Genomics
IS - 12
ER -