Liver transplantation outcome in patients with angiographically proven coronary artery disease: A multi-institutional study

C. Wray, J. C. Scovotti, J. Tobis, C. U. Niemann, R. Planinsic, A. Walia, J. Findlay, G. Wagener, J. B. Cywinski, D. Markovic, C. Hughes, A. Humar, A. Olmos, R. Sierra, R. Busuttil, R. H. Steadman

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Over the last decade the age of liver transplant (LT) recipients and the likelihood of coronary artery disease (CAD) in this population have increased. There are no multicenter studies that have examined the impact of CAD on LT outcomes. In this historical cohort study, we identified adult LT recipients who underwent angiography prior to transplantation at seven institutions over a 12-year period. For each patient we recorded demographic data, recipient and donor risk factors, duration of follow-up, the presence of angiographically proven obstructive CAD (≥50% stenosis) and post-LT survival. Obstructive CAD was present in 151 of 630 patients, the CAD(+) group. Nonobstructive CAD was found in 479 patients, the CAD(-) group. Patient survival was similar for the CAD(+) group (adjusted HR 1.13, CI = [0.79, 1.62], p = 0.493) compared to the CAD(-) group. The CAD(+) patients were further stratified into severe (CADsev, >70% stenosis, n = 96), and moderate CAD (CADmod, 50-70% stenosis, n = 55) groups. Survival for the CADsev (adjusted HR = 1.26, CI = [0.83, 1.91], p = 0.277) and CADmod (adjusted HR = 0.93, CI = [0.52, 1.66], p = 0.797) groups were similar to the CAD(-) group. We conclude that when current CAD treatment strategies are employed prior to transplant, post-LT survival is not significantly different between patients with and without obstructive CAD. The authors find no significant difference in post-liver transplant survival between patients with and without angiographically proven obstructive coronary artery disease when current treatment regimens are employed.

Original languageEnglish (US)
Pages (from-to)184-191
Number of pages8
JournalAmerican Journal of Transplantation
Volume13
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Coronary artery disease
  • end-stage liver disease
  • liver transplantation
  • mortality
  • survival

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Liver transplantation outcome in patients with angiographically proven coronary artery disease: A multi-institutional study'. Together they form a unique fingerprint.

Cite this