Liver transplantation in patients with fulminant hepatitis B: experience in Canton, China.

Xiaofeng Zhu, Guihua Chen, Xiaoshun He, Minqiang Lu, Guodong Wang, Changjie Cai, Yang Yang, Jiefu Huang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

OBJECTIVE: To investigate the effect of orthotopic liver transplantation on fulminant hepatitis B and the preventive efficiency of lamivudine on recurrence of hepatitis B in China. PATIENTS AND METHODS: Ten patients with fulminant hepatitis B received orthotopic liver transplantation under veno-venous bypass. All patients had preoperatively serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy, 2 with acute renal failure, and 1 with gastro-hemorrhage. RUSULT: Seven of the 10 patients have survived for 3 approximately 18 months, but 3 died of multi-organ failure or recurrence of fulminant hepatitis B. Seven survivors took lamivudine and 6 of them have survived for 3 approximately 18 months without the signs of recurrence of hepatitis B. CONCLUSION: Orthotopic liver transplantation is an effective therapy for fulminant hepatitis B, and lamivudine may prevent recurrence of hepatitis B after transplantation.

Original languageEnglish (US)
Pages (from-to)44-46
Number of pages3
JournalChinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences
Volume17
Issue number1
StatePublished - Mar 2002

ASJC Scopus subject areas

  • Medicine(all)

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