Liver Transplantation in a Patient With Antiphospholipid Syndrome: A Case Report

Rachel C. Steckelberg, Zarah D. Antongiorgi, Randolph H. Steadman

Research output: Contribution to journalArticle

Abstract

Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder characterized by autoantibodies to cell membrane phospholipids. While altered coagulation can complicate end-stage liver disease, there are few reports describing the perioperative management for liver transplantation in recipients with a preexisting hypercoagulable disorder, such as APS. We present a patient with a history of APS, Budd-Chiari syndrome with cirrhosis, hepatopulmonary syndrome, and heparin-induced thrombocytopenia who underwent liver transplantation complicated by hepatic artery thrombosis. Management included postoperative anticoagulation with a factor Xa inhibitor and, after repeat transplantation, transition to long-term anticoagulation therapy with eventual recovery.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalA & A case reports
Volume9
Issue number5
DOIs
StatePublished - Sep 1 2017

ASJC Scopus subject areas

  • Medicine(all)

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