TY - JOUR
T1 - Liver toxicity of lopinavir-containing regimens in HIV-infected patients with or without hepatitis C coinfection
AU - González-Requena, Daniel
AU - Núñez, Marina
AU - Jiménez-Nacher, Inmaculada
AU - González-Lahoz, Juan
AU - Soriano, Vincent
PY - 2004/7
Y1 - 2004/7
N2 - Liver toxicity is a common side effect of antiretroviral therapy, particularly in subjects coinfected with the hepatitis C virus (HCV). The incidence of severe liver toxicity after initiation of treatment with lopinavir (LPV) as well as its possible association with LPV plasma levels were assessed in 120 HIV-infected patients (52% coinfected by HCV). The incidence of severe liver toxicity at 3 months was 1.7% and the cumulative incidence at 12 months was 4%. The development of severe liver toxicity was associated with HCV coinfection but not with LPV plasma levels.
AB - Liver toxicity is a common side effect of antiretroviral therapy, particularly in subjects coinfected with the hepatitis C virus (HCV). The incidence of severe liver toxicity after initiation of treatment with lopinavir (LPV) as well as its possible association with LPV plasma levels were assessed in 120 HIV-infected patients (52% coinfected by HCV). The incidence of severe liver toxicity at 3 months was 1.7% and the cumulative incidence at 12 months was 4%. The development of severe liver toxicity was associated with HCV coinfection but not with LPV plasma levels.
UR - http://www.scopus.com/inward/record.url?scp=3843086137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843086137&partnerID=8YFLogxK
U2 - 10.1089/0889222041524562
DO - 10.1089/0889222041524562
M3 - Article
C2 - 15307912
AN - SCOPUS:3843086137
SN - 0889-2229
VL - 20
SP - 698
EP - 700
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 7
ER -