Liver toxicity caused by nevirapine

Daniel González De Requena; Marina Núñez; Inmaculada Jiménez-Nácher; Vincent Soriano

doi:10.1097/00002030-200201250-00020

Liver toxicity caused by nevirapine

Daniel González De Requena, Marina Núñez, Inmaculada Jiménez-Nácher, Vincent Soriano

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 μg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.

Original language	English (US)
Pages (from-to)	290-291
Number of pages	2
Journal	AIDS
Volume	16
Issue number	2
DOIs	https://doi.org/10.1097/00002030-200201250-00020
State	Published - Jan 25 2002

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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abstract = "Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 μg/ml were associated with a 92\% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.",

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AU - González De Requena, Daniel

AU - Núñez, Marina

AU - Jiménez-Nácher, Inmaculada

AU - Soriano, Vincent

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Y1 - 2002/1/25

N2 - Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 μg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.

AB - Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 μg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.

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Liver toxicity caused by nevirapine

Abstract

ASJC Scopus subject areas

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