TY - JOUR
T1 - Liver toxicity caused by nevirapine
AU - González De Requena, Daniel
AU - Núñez, Marina
AU - Jiménez-Nácher, Inmaculada
AU - Soriano, Vincent
PY - 2002/1/25
Y1 - 2002/1/25
N2 - Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 μg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.
AB - Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 μg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.
UR - http://www.scopus.com/inward/record.url?scp=0037169260&partnerID=8YFLogxK
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U2 - 10.1097/00002030-200201250-00020
DO - 10.1097/00002030-200201250-00020
M3 - Article
C2 - 11807315
AN - SCOPUS:0037169260
SN - 0269-9370
VL - 16
SP - 290
EP - 291
JO - AIDS
JF - AIDS
IS - 2
ER -