TY - JOUR
T1 - Liver injury after beginning antiretroviral therapy in HIV/hepatitis C virus co-infected patients is not related to immune reconstitution
AU - Martín-Carbonero, Luz
AU - Núñez, Marina
AU - Ríos, Pilar
AU - Pérez-Olmeda, Mayte
AU - González-Lahoz, Juan
AU - Soriano, Vincent
PY - 2002/7/5
Y1 - 2002/7/5
N2 - Transaminase elevations occur more frequently after beginning antiretroviral therapy in HIV-positive patients co-infected with hepatitis C virus (HCV). The mechanism of liver injury in these individuals is unknown, although immune reconstitution phenomena have been postulated. In 42 HIV/HCV co-infected individuals followed after beginning potent antiretroviral therapy, the development of liver injury was not associated with significant changes in serum HCV-RNA levels nor with greater CD4 cell increases. Underlying chronic hepatitis may thus increase the risk of liver toxicity by other mechanisms.
AB - Transaminase elevations occur more frequently after beginning antiretroviral therapy in HIV-positive patients co-infected with hepatitis C virus (HCV). The mechanism of liver injury in these individuals is unknown, although immune reconstitution phenomena have been postulated. In 42 HIV/HCV co-infected individuals followed after beginning potent antiretroviral therapy, the development of liver injury was not associated with significant changes in serum HCV-RNA levels nor with greater CD4 cell increases. Underlying chronic hepatitis may thus increase the risk of liver toxicity by other mechanisms.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037024767&partnerID=8YFLogxK
U2 - 10.1097/00002030-200207050-00016
DO - 10.1097/00002030-200207050-00016
M3 - Article
C2 - 12131221
AN - SCOPUS:0037024767
SN - 0269-9370
VL - 16
SP - 1423
EP - 1425
JO - AIDS
JF - AIDS
IS - 10
ER -