Liver hemostasis using high-intensity focused ultrasound

Shahram Vaezy; Roy W. Martin; Udo Schmiedl; Michael Caps; Shari Taylor; Kirk Beach; Steve Carter; Peter Kaczkowski; George Keilman; Scott Helton; Wayne Chandler; Pierre Mourad; Matthew Rice; Ronald Roy; Lawrence Crum

doi:10.1016/S0301-5629(97)00143-9

Liver hemostasis using high-intensity focused ultrasound

Shahram Vaezy, Roy W. Martin, Udo Schmiedl, Michael Caps, Shari Taylor, Kirk Beach, Steve Carter, Peter Kaczkowski, George Keilman, Scott Helton, Wayne Chandler, Pierre Mourad, Matthew Rice, Ronald Roy, Lawrence Crum

Houston Methodist

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

Liver hemorrhage, the major cause of death in hepatic trauma, is notoriously difficult to control. We report on the use of high-intensity focused ultrasound (HIFU) to arrest the bleeding from incisions made in rabbit livers. A HIFU transducer, with a spherically curved aperture of 6.34 cm² area, a focal length of 4 cm and a frequency of 3.3 MHz was used. In approximately 94% of the incisions, the hemorrhage was reduced to a slow oozing of blood in less than 2 min. The maximum temperature of liver tissue around the incision area, during HIFU application was measured to be 86°C. The mechanism of hemostasis, confirmed by histological examination, appears to be coagulative necrosis of a volume of liver tissue around the incision. We believe that acoustic hemostasis, with the unique characteristic of 'volume cauterization,' offers a novel method for the management of liver hemorrhage and, thus, has major clinical implications.

Original language	English (US)
Pages (from-to)	1413-1420
Number of pages	8
Journal	Ultrasound in Medicine and Biology
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/S0301-5629(97)00143-9
State	Published - 1997

Keywords

Acoustic hemostasis
Coagulative necrosis
Hemorrhage
HIFU
Liver
Rabbit
Surgery
Temperature
Trauma
Ultrasound

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1016/S0301-5629(97)00143-9

Cite this

@article{003346d72a7c46688aa5f4230f6ab3a0,

title = "Liver hemostasis using high-intensity focused ultrasound",

abstract = "Liver hemorrhage, the major cause of death in hepatic trauma, is notoriously difficult to control. We report on the use of high-intensity focused ultrasound (HIFU) to arrest the bleeding from incisions made in rabbit livers. A HIFU transducer, with a spherically curved aperture of 6.34 cm2 area, a focal length of 4 cm and a frequency of 3.3 MHz was used. In approximately 94% of the incisions, the hemorrhage was reduced to a slow oozing of blood in less than 2 min. The maximum temperature of liver tissue around the incision area, during HIFU application was measured to be 86°C. The mechanism of hemostasis, confirmed by histological examination, appears to be coagulative necrosis of a volume of liver tissue around the incision. We believe that acoustic hemostasis, with the unique characteristic of 'volume cauterization,' offers a novel method for the management of liver hemorrhage and, thus, has major clinical implications.",

keywords = "Acoustic hemostasis, Coagulative necrosis, Hemorrhage, HIFU, Liver, Rabbit, Surgery, Temperature, Trauma, Ultrasound",

author = "Shahram Vaezy and Martin, {Roy W.} and Udo Schmiedl and Michael Caps and Shari Taylor and Kirk Beach and Steve Carter and Peter Kaczkowski and George Keilman and Scott Helton and Wayne Chandler and Pierre Mourad and Matthew Rice and Ronald Roy and Lawrence Crum",

note = "Funding Information: Acknowledgement-We acknowledge the support of the Defense Advanced Research Programs Administration under its MURI program. This work was supported by a grant from DARPA. Number NOOOIJ-96-0630.",

year = "1997",

doi = "10.1016/S0301-5629(97)00143-9",

language = "English (US)",

volume = "23",

pages = "1413--1420",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Liver hemostasis using high-intensity focused ultrasound

AU - Vaezy, Shahram

AU - Martin, Roy W.

AU - Schmiedl, Udo

AU - Caps, Michael

AU - Taylor, Shari

AU - Beach, Kirk

AU - Carter, Steve

AU - Kaczkowski, Peter

AU - Keilman, George

AU - Helton, Scott

AU - Chandler, Wayne

AU - Mourad, Pierre

AU - Rice, Matthew

AU - Roy, Ronald

AU - Crum, Lawrence

N1 - Funding Information: Acknowledgement-We acknowledge the support of the Defense Advanced Research Programs Administration under its MURI program. This work was supported by a grant from DARPA. Number NOOOIJ-96-0630.

PY - 1997

Y1 - 1997

N2 - Liver hemorrhage, the major cause of death in hepatic trauma, is notoriously difficult to control. We report on the use of high-intensity focused ultrasound (HIFU) to arrest the bleeding from incisions made in rabbit livers. A HIFU transducer, with a spherically curved aperture of 6.34 cm2 area, a focal length of 4 cm and a frequency of 3.3 MHz was used. In approximately 94% of the incisions, the hemorrhage was reduced to a slow oozing of blood in less than 2 min. The maximum temperature of liver tissue around the incision area, during HIFU application was measured to be 86°C. The mechanism of hemostasis, confirmed by histological examination, appears to be coagulative necrosis of a volume of liver tissue around the incision. We believe that acoustic hemostasis, with the unique characteristic of 'volume cauterization,' offers a novel method for the management of liver hemorrhage and, thus, has major clinical implications.

AB - Liver hemorrhage, the major cause of death in hepatic trauma, is notoriously difficult to control. We report on the use of high-intensity focused ultrasound (HIFU) to arrest the bleeding from incisions made in rabbit livers. A HIFU transducer, with a spherically curved aperture of 6.34 cm2 area, a focal length of 4 cm and a frequency of 3.3 MHz was used. In approximately 94% of the incisions, the hemorrhage was reduced to a slow oozing of blood in less than 2 min. The maximum temperature of liver tissue around the incision area, during HIFU application was measured to be 86°C. The mechanism of hemostasis, confirmed by histological examination, appears to be coagulative necrosis of a volume of liver tissue around the incision. We believe that acoustic hemostasis, with the unique characteristic of 'volume cauterization,' offers a novel method for the management of liver hemorrhage and, thus, has major clinical implications.

KW - Acoustic hemostasis

KW - Coagulative necrosis

KW - Hemorrhage

KW - HIFU

KW - Liver

KW - Rabbit

KW - Surgery

KW - Temperature

KW - Trauma

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=0030695428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030695428&partnerID=8YFLogxK

U2 - 10.1016/S0301-5629(97)00143-9

DO - 10.1016/S0301-5629(97)00143-9

M3 - Article

C2 - 9428140

AN - SCOPUS:0030695428

VL - 23

SP - 1413

EP - 1420

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 9

ER -

Liver hemostasis using high-intensity focused ultrasound

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this