Live cell imaging fails to support viral-protein-mediated intercellular trafficking

Fuqing Wu, Jing Long, Shuai Wang, Junji Xing, Meili Li, Chunfu Zheng

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The herpes simplex virus type I protein VP22 has been reported to have the property of intercellular trafficking. However, there is little direct evidence to demonstrate that VP22 can shuttle freely between living cells. Here, we employ a novel and simple assay using live cell fluorescence microscopy to investigate the intercellular transport property. Our results demonstrated that VP22, bovine herpesvirus-1 VP22, HSV-1 US11 and HIV Tat could not shuttle into neighboring cells via direct contact.

Original languageEnglish (US)
Pages (from-to)1383-1386
Number of pages4
JournalArchives of Virology
Volume157
Issue number7
DOIs
StatePublished - Jul 1 2012

ASJC Scopus subject areas

  • Virology

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